Knee pain continues to be one of the most common orthopedic complaints among adults—especially those living with osteoarthritis. If you’re dealing with daily discomfort, stiffness, or swelling, you may be wondering: what is the newest treatment for knee pain in 2025?
Fortunately, advances in medical technology are giving patients more options than ever—without jumping straight to knee replacement surgery. One of the most promising developments? A minimally invasive procedure called Genicular Artery Embolization (GAE).
Let’s take a quick look at some of the latest techniques being used to relieve knee pain in 2025:
This regenerative therapy uses a concentration of your own blood’s platelets to promote healing. While promising, results vary and long-term effectiveness is still under review.
Still considered experimental in many settings, stem cell therapy aims to rebuild cartilage. It’s not yet widely available or covered by insurance—and studies are ongoing.
This treatment uses heat to interrupt pain signals sent from the knee to the brain. It may be effective for some types of chronic knee pain, especially in patients who aren’t surgical candidates.
GAE is one of the most exciting advancements for osteoarthritis-related knee pain. It’s non-surgical, minimally invasive, and offers long-term relief for the right candidates. Here’s how it works.
GAE is a procedure performed by a vascular specialist to target the tiny arteries that supply blood to the inflamed lining of the knee joint. In osteoarthritis, these arteries grow abnormally and contribute to chronic inflammation and pain.
During the procedure:
A small catheter is inserted (usually through the wrist or groin)
The physician uses imaging to guide it to the genicular arteries
Tiny particles are injected to block abnormal blood flow
Inflammation is reduced, and pain often improves significantly
Most patients go home the same day and return to light activity in just a couple of days.
Read how Genicular Artery Embolization works and whether you’re a candidate.
GAE isn’t just new—it’s also effective, safe, and increasingly accessible. Here’s why more patients are asking about it:
Non-surgical and outpatient
Short recovery time
No joint replacement required
Lasting pain relief (often 12+ months)
Preserves the knee joint
Covered by some insurance plans
It’s especially helpful for patients in the moderate stages of osteoarthritis—when conservative treatments have failed, but full joint replacement still feels too drastic.
You might be a good candidate if:
You’ve been diagnosed with osteoarthritis of the knee
You still have pain after trying therapy, injections, or medications
You want to avoid or delay surgery
You’re looking for a long-term treatment without major recovery
Our providers in Cleveland and Atlanta offer GAE evaluations to help you determine the best next step.
If you’re searching for the newest treatment for knee pain in 2025, Genicular Artery Embolization should be on your radar. It offers real relief—without the risk, recovery, or commitment of surgery.
Schedule a consultation to find out if GAE is right for you and start walking toward relief.
